A systematic review: Advanced magnetic nanotheranostics
1 Department of Chemistry, Government College University Faisalabad, Pakistan.
2 Department of Zoology, University of Okara, Pakistan.
Review
Comprehensive Research and Reviews in Engineering and Technology, 2022, 01(01), 024–028.
Article DOI: 10.57219/crret.2022.1.1.0024
Publication history:
Received on 27 July 2022; revised on 03 September 2022; accepted on 08 September 2022
Abstract:
Scientific progress in chemistry, physics, technology, and medicine has led to the development of high-sensitivity biomedical imaging systems, crucial for identifying illnesses and interpreting physiological phenomena. Modalities like MRI, PET, CT, SPECT, optical fluorescence imaging, ultrasound, and photoacoustic imaging are widely used. The pursuit of precise imaging has driven the exploration of multi-modality approaches, combining the strengths of different modalities. Magnetic nanoparticles, due to their customizable features, have become a key platform for contrast agents in MRI. Their adaptability also makes them valuable in multi-modal imaging, combining features like MRI-optical and MRI-PET/SPECT for precise imaging. Current discussion delves into the unique magnetic properties of nanoparticles, their synthesis methods, and applications across diverse fields. External magnetic fields play a role in the agglomeration of superparamagnetic iron oxide nanoparticles (SPIONs), impacting their biological effects. In nanomedicine, engineered magnetic nanoparticles guide drug delivery, hyperthermia cancer therapy, and tissue engineering. However, concerns arise about increased cytotoxicity and resistance to biodegradation compared to bulk counterparts. Moreover, role of magnetic stimuli in neurogenesis, emphasizing both potential benefits and risks. Additionally, a magneto-nanomechanical approach is discussed, involving the mechanical activation of functionalized magnetic nanoparticles for targeted drug delivery and cancer cell destruction. The application of magnetic nanoparticles as carriers for therapeutic DNA, particularly in gene delivery using surface-modified nanoparticles, represents a promising avenue for cancer management. The text underscores the need for further research to optimize parameters for in vitro and in vivo treatments. Overall, the integration of magnetic nanoparticles in various biomedical applications showcases their versatility and potential impact on advancing medical technologies.
Keywords:
Molecular Imaging; Magnetic Nanoparticles; Nanomedicine; MRI; Nanotheranostics; Multimodal Imaging Agents; Contrast Agents
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